VALCHLOR® (mechlorethamine) gel is an alkylating drug indicated for the topical treatment of Stage IA and IB mycosis fungoides–type cutaneous T-cell lymphoma (MF-CTCL) in patients who have received prior skin-directed therapy

Proven treatment with an FDA-approved formulation1

VALCHLOR gel* is a clear, quick-drying formulation of mechlorethamine2

VALCHLOR gel can fit into patients' daily routine

VALCHLOR gel can fit into patients' daily routine

Once-daily self-administration icon

Once-daily self-administration2

Applied at the patient's discretion

Can be used with emollients icon

Can be used with emollients2

2 hours before/after application

Clear, non-greasy gel icon

Clear, non-greasy gel2

Once dry, unlikely to stain clothing/sheets

Dries quickly icon

Dries quickly2

5-10 minutes after application

See special handling and disposal considerations for VALCHLOR

  • Mechlorethamine (nitrogen mustard) is an effective topical treatment for cutaneous lymphoma with nearly 70 years of data2,3

*Each tube of VALCHLOR gel contains gel 0.016% w/w of mechlorethamine (equivalent to 0.02% mechlorethamine HCl).2

VALCHLOR gel is the only FDA-approved topical formulation of mechlorethamine
manufactured with consistent quality for your patients.2


  1. Lymphoma Research Foundation. Getting the facts: cutaneous T-cell lymphoma. Lymphoma Research Foundation website. Updated August 2017. Accessed November 19, 2018.
  2. VALCHLOR [package insert]. Iselin, NJ: Helsinn Therapeutics US, Inc.; January 2020.
  3. Lessin SR, Duvic M, Guitart J, et al. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. Arch Dermatol. 2012;E1-E8.