VALCHLOR® (mechlorethamine) gel is an alkylating drug indicated for the topical treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (MF‑CTCL) in patients who have received prior skin-directed therapy

When it’s time to manage the challenges of Stage IA and IB MF‑CTCL Valchlor is on it
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When it’s time to manage the challenges of Stage IA and IB MF‑CTCL Valchlor is on it

The first and only FDA-approved topical formulation of mechlorethamine (commonly known as nitrogen mustard)

  • Proven efficacy in a 12-month study1
  • Once-daily gel (special handling and disposal procedures should be followed during use)
  • Dependable formulation manufactured with consistent quality and potency
  • Comprehensive resources provided by VALCHLOR Support

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

VALCHLOR is contraindicated in patients with known severe hypersensitivity to mechlorethamine. Hypersensitivity reactions, including anaphylaxis, have occurred with topical formulations of mechlorethamine.

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS

The most common adverse reactions (≥5%) were dermatitis (56%), pruritus (20%), bacterial skin infection (11%), skin ulceration or blistering (6%), and hyperpigmentation (5%). These reactions may be moderately severe or severe. Elderly patients aged 65 and older may be more susceptible. Depending on severity, treatment reduction, suspension, or discontinuation may be required.

DOSING AND APPLICATION

VALCHLOR is for topical dermatologic use only. Apply a thin film of gel once daily to affected areas of the skin. VALCHLOR is a cytotoxic drug and special handling and disposal procedures should be followed during use. Caregivers must wear disposable nitrile gloves when applying VALCHLOR. Patients and caregivers must wash hands thoroughly after handling or applying VALCHLOR.

To report SUSPECTED ADVERSE REACTIONS, contact Actelion Pharmaceuticals US, Inc., at 1‑855‑4‑VALCHLOR (1‑855‑482‑5245) or FDA at 1‑800‑FDA‑1088 or visit www.fda.gov/medwatch.

Please see VALCHLOR full Prescribing Information.